Elucidating the pathway for arsenic methylation speed dating dorchester dorset
MTRR: (methionine synthase reductase) responsible for the regeneration of methyl-B-12.
SHMT: (serine hydroxymethyltransferase) responsible for catalyzing the interconversion of glycine to serine.
SUOX: (sulfite oxidase) mitochondrial enzyme responsible for oxidizing sulfites to sulfates.
Sulfites are produced by the transsulfuration cycle or from diet.
While several studies may identify effects on other endpoints at the same exposure level that produces dermal effects, the database for dermal effects is stronger than for effects on other endpoints [ATSDR 2007] Key physiologic effects from arsenic exposure that will be covered in detail later.
Note that when strength of association (defined as the magnitude of the relative risk in the exposed group compared with that in the control group) is mentioned throughout this section, it refers to one of the five criteria used to decide whether a positive association in epidemiologic studies indicates causality.
In addition, fulfillment of some criteria may occur when the association is a result of chance or bias.
The DNA Methylation Pathway Profile allows clinicians to screen their patients for a variety of genetic changes (single nucleotide polymorphisms, or SNPs) that may impact the function of important biochemical processes such as methionine metabolism, detoxification, hormone balance and Vitamin D function.
The presence or absence of SNPs may modify disease risk.
This reaction allows for the conversion of homocysteine to methionine.
MTR: (methionine synthase) enzyme that catalyzes the re-methylation of homocysteine to methionine using the methyl-B-12 as a cofactor.The identification of SNPs and their impact on health and physiology is an ongoing area of research – the hope is that finding and studying these small variations in DNA will lead to better and more individualized medical interventions.